Cells regulate actin filament assembly to drive a wide range of fundamental
cellular processes such as division, establishing polarity, endocytosis,
mating and motility. The focus of our research group is to determine the
molecular biochemical mechanisms that govern how the model systems fission
yeast (Schizosaccharomyces pombe) and nematode worm (Caenorhabditis
elegans) coordinate actin assembly through diverse actin associated
proteins. We utilize multiple techniques both in and out of live cells
including genetics, fluorescence microscopy, biochemistry, biophysics
and innovative single actin filament imaging assays (movie).


